【单选题】
20. The schoolboy ______ a blind man cross the street yesterday. A. helps B. helped C. will help D. has helped
A. A
B. B
C. C
D. D
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答案
B
解析
B
相关试题
【单选题】
21. —The 2010 World Expo which will last 184 days will be held in Shanghai on May 1st. —________exciting news! We shall try our best to support it. A. How B. How an C. What D. What an
A. A
B. B
C. C
D. D
【单选题】
22. They preferred ______ in bed rather than _____ horses.    A. to lie; to ride B. lying; riding C. lying; ride D. to lie; ride
A. A
B. B
C. C
D. D
【单选题】
23. —What was Jim wearing at the party? — Nothing _______. He was in his usual shirt and jeans. A. special B. simple C. important D. interesting
A. A
B. B
C. C
D. D
【单选题】
24. The 2016 Olympic Games ________ in Brazil. Would you like to go there? Maybe, if possible. A. are held B. will be held C. were held D. have been held
A. A
B. B
C. C
D. D
【单选题】
25. — David, look at the man in white over there.Can you tell me _______ ? —He is a doctor.    A. who is he B. who he is C.what does he do D. what he does
A. A
B. B
C. C
D. D
【单选题】
( ) 26.With help from a Mr. H, you can__________. A. stop wearing your watch B. get new books and objects C. finish your homework on time D. know when parents or teachers are near
A. A
B. B
C. C
D. D
【单选题】
( ) 27. A PENGO WATCH CONTROL can help you to ______________. A. repair your TV B. put away your books and objects C. become a James Bond D. get a daily weather report
A. A
B. B
C. C
D. D
【单选题】
( ) 28. You can get your Mr. H for___________. A. $299 B. $499 C. $199 D. $99
A. A
B. B
C. C
D. D
【单选题】
( ) 29. When was canned food invented? A. In 1870.          B. In 1810. C. In 1902.          D. In 1926.
A. A
B. B
C. C
D. D
【单选题】
( ) 30. After the trip to the Arctic, Clarence Birdseye invented ____________. A. canned food             B. can openers C. frozen food           D. air conditioning
A. A
B. B
C. C
D. D
【单选题】
( ) 31. Changes in weather _____________ in Willis Carrier's company. A. helped to keep food           B. made rooms comfortable C. caused health problems        D. hurt printing paper
A. A
B. B
C. C
D. D
【单选题】
( ) 32. According to the passage, which of the following may lead to inventions? A. People's needs.             B. Public support. C. Modern technology.          D. Practical suggestions.
A. A
B. B
C. C
D. D
【单选题】
( ) 33. What is the writer's main purpose(目的)in writing this passage?    A.To tell the readers his life story.    B.To tell people what kind of person his father was.    C.To tell the readers what present he got from his father.    D. To let people know how poor he was.
A. A
B. B
C. C
D. D
【单选题】
( ) 34. Why did the father not ask his son not to do this and do that?    A.Because he felt quite confident of his son.    B.Because he was born from a poor family.    C.Because he was a man of few words.    D.Because he didn't want to be much too strict with his son.
A. A
B. B
C. C
D. D
【单选题】
( ) 35. What would someone learn from this passage?    A.How to live by oneself. B.How to stand on one's own feet.    C.What a good father should do. D.What the self-important is like.
A. A
B. B
C. C
D. D
【单选题】
( ) 36. What may be the proper Chinese for the underlined part in the passage?    A.闲暇时光 B.学费 C.精神空虚 D.经济不足
A. A
B. B
C. C
D. D
【单选题】
( ) 37. The Chinese Yellow Sea Wetlands are in the _______ of China.    A.south           B.east    C.west            D.north
A. A
B. B
C. C
D. D
【单选题】
( ) 38. Usually the weather in the wetlands is _______.    A.hot             B.pleasant   C.cold            D.dry
A. A
B. B
C. C
D. D
【单选题】
( ) 39. The World Wetlands Day is on _______.    A.February 2        B.June 25   C.April 22      D.March
A. A
B. B
C. C
D. D
【单选题】
( ) 40. We must protect wetlands because _______. A.they are home for wildlife   B.they can prevent flood    C.they can offer food to the animals and birds D.all of the above
A. A
B. B
C. C
D. D
【单选题】
) 1. —Is it far from here to the bank? —Not very, only________. A. 20 minute’s walk B. 20 minutes walk C. 20 minutes’ walk D. 20 minutes’ walks
A. A
B. B
C. C
D. D
【单选题】
2. — After discussing, the students ________ some good ideas to work on the project. — Thats great! A. put up B. set up C. caught up with D. came up with
A. A
B. B
C. C
D. D
【单选题】
3. Yesterday Tommy walked past my table and ______ my bowls and dishes. He should be careful next time. A. knocked off B. took off C. showed off D. turned off
A. A
B. B
C. C
D. D
【单选题】
4.We don’t have enough nurses to look after patients.At least ___ nurses are needed. A. ten another B. more ten C. another ten D. other ten
A. A
B. B
C. C
D. D
【单选题】
5. — Zhao Rui, it’s said that many famous singers will come to Yangzhou on April 18th. How about watching the evening show there? —________! Let’s ask Huang Tao to go with us. A. Best wishes B. Sounds great C. Good luck D. That’s OK
A. A
B. B
C. C
D. D
【单选题】
6.—Hello! This is Henry Speaking.I’d like to speak to your father. —Sorry, he has Shanghai. A. been in B. been to C. come to D. gone to
A. A
B. B
C. C
D. D
【单选题】
7. — It’s difficult for the village children to cross the river for school. — I think a bridge ______ over the river. A. was built B. is being built C. has been built D. should be built
A. A
B. B
C. C
D. D
【单选题】
8. —Where would you like to go, Jinan or Qufu? — .I only want to go to Qingdao. A. Each B. Either C. Neither D. All
A. A
B. B
C. C
D. D
【单选题】
9 — The documentary A Bite Of China II is quite popular around China recently. How do you like it? ______. A. I think so B. Pretty good C. Its my pleasure D. All right
A. A
B. B
C. C
D. D
【单选题】
10. There are three English-books on the shelf, but ______ of them is mine. A. both B. neither C.all D. none
A. A
B. B
C. C
D. D
【单选题】
11. When the parents arrived at the hall, the students _______ their projects. A. have finish B. finished C. had finished D. are finishing
A. A
B. B
C. C
D. D
【单选题】
12. This week, the _______ seems to change every day: one day is hot; the next day is cold. A. time B. weather C. season D. way
A. A
B. B
C. C
D. D
【单选题】
13. He never does his work _______ Mary.    A. as careful as B. so careful as C. carefully as D. as carefully
A. A
B. B
C. C
D. D
【单选题】
14. — Can he jump high? — Yes, he ______. He is a good high jumper. A. must B. need C. can D. shall
A. A
B. B
C. C
D. D
【单选题】
15. The shop _____ at 8:00 a.m.and it ________ for ten hours every day. A. is open; has opened B. is opened; opens C. opens; is open D. opened; opens
A. A
B. B
C. C
D. D
【单选题】
16. —Excuse me, may I use your bicycle? ______ is broken. Certainly. But remember to return it before lunch. A. Mine B. Me C. Myself D. I
A. A
B. B
C. C
D. D
【单选题】
17. Simon, what do I need to take for the hiking? Youd better ________ more water than usual. Its hot today. A. to take B. taking C. take D. took
A. A
B. B
C. C
D. D
【单选题】
18. Helen ______ to a language school when she was seven. A. sent B. is sent C. will send D. was sent
A. A
B. B
C. C
D. D
【单选题】
19. — Is this park youve visited recently? — Yes, it's the most beautiful one Ive ever visited before. A. that B. the one C. which D. the one which
A. A
B. B
C. C
D. D
【单选题】
20. — Its difficult for the village children to cross the river for school. — I think a bridge ________ over the river. A. should be built B. is being built C. has been built D. was built
A. A
B. B
C. C
D. D
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【多选题】
根据ELN指南,达到满意疗效的Bcr-Abl转录本的水平是( )。
A. TKI 治疗3个月,Bcr-Abl : ≤ 10%
B. TKI 治疗6个月,Bcr-Abl : ≤ 1%
C. TKI 治疗12个月,Bcr-Abl :≤0.1%
D. 所有选项均不正确
【多选题】
服用达希纳时,应注意的事项有( )。
A. 电解质异常
B. 肝功能异常
C. 血清脂肪酶升高
D. QT间期延长
【多选题】
服用达希纳时,如果出现有显著临床意义的中度或严重的非血液学毒性,应该暂停服药。
A. 是
B. 否
C. QQ
D. PP
【多选题】
服用达希纳时,任何时候都应该避免进食( )。
A. 葡萄柚汁
B. 苹果汁
C. 已知的有抑制CYP3A4作用的食物
D. 香蕉汁
【多选题】
达希纳能够抑制( )激酶的自磷酸化。
A. Bcr-Abl(20-60nM)
B. PDGFR(69nM)
C. Src
D. c-Kit(210nM)
【多选题】
达希纳胶囊服用时,可以咀嚼或吮吸,可以打开胶囊。
A. 是
B. 否
C. QQ
D. PP
【多选题】
达希纳含有乳糖,所以对于( )的患者,不推荐使用。
A. 半乳糖不耐受症
B. 严重的乳糖酶缺陷
C. 葡萄糖-半乳糖吸收障碍
D. 所有选项均不正确
【多选题】
达希纳服用时,如果错过给药,患者不得另外补充剂量,而是按照处方服用下一次剂量。
A. 是
B. 否
C. QQ
D. PP
【多选题】
达希纳不可以与羟基脲或阿那格雷联用。
A. 是
B. 否
C. QQ
D. PP
【多选题】
伴有( )的患者禁用达希纳。
A. 低钾血症
B. 低镁血症
C. 长QT综合征
D. 所有选项均不正确
【多选题】
TKI治疗均的CV风险管理中,属于可更改的因素有( )。
A. 高血压
B. 吸烟
C. 糖尿病
D. 饮食
【多选题】
TKI治疗均的CV风险管理中,属于不可更改的因素有( )。
A. 年龄
B. 性别
C. 家族史
D. 血脂
【多选题】
ENESTnd研究中的分组有( )。
A. 达希纳300mg BID
B. 达希纳400mg BID
C. 伊马替尼400mg QD
D. 伊马替尼400mg BID
【多选题】
ENESTnd研究中,在5年随访中,所有时间点达希纳组MMR的比例始终高于伊马替尼组。
A. 是
B. 否
C. QQ
D. PP
【多选题】
ENESTnd研究中,与伊马替尼相比,达希纳一线治疗组疾病进展至AP/BC显著更少。
A. 是
B. 否
C. QQ
D. PP
【多选题】
ENESTnd研究中,排除( )类型的患者。
A. 临床显著的心动过缓
B. 近期的心肌梗死
C. 充血性心脏衰竭
D. 不稳定型心绞痛
【多选题】
ENESTnd研究中,从第一年至第五年的随访中,达希纳和伊马替尼组累积的MR4.5相差的比例保持完全不变。
A. 是
B. 否
C. QQ
D. PP
【多选题】
ENESTnd标志性分析中,3个月时获得BCR-ABLIS≤10%与60个月时更佳的OS无关
A. 是
B. 否
C. QQ
D. PP
【多选题】
在TIDEL-II研究中,服用伊马替尼二线治疗的患者在3个月时没有达到EMR的比例为
A. 0.08
B. 0.09
C. 0.12
D. 0.15
【多选题】
在ENESTnd研究中,在伊马替尼400mg每天治疗失败后将剂量增加至600或800 mg每天不会导致超过一半的患者反应改善。
A. 是
B. 否
C. QQ
D. PP
【多选题】
在ENESTnd研究所有风险组中,伊马替尼治疗的EMR失败率比达希纳高3-4倍。
A. 是
B. 否
C. QQ
D. PP
【多选题】
在ENESTnd或DASISION研究中,5年随访时,伊马替尼二线治疗组获得MR4.5的中位时间均未达到。
A. 是
B. 否
C. QQ
D. PP
【多选题】
"与竞品达沙替尼相比,达希纳精准强效抑制BCR-ABL
A. 是
B. 否
C. QQ
D. PP
【多选题】
与竞品达沙替尼相比,达希纳非血液学不良反应交叉不耐受发生率高?
A. 是
B. 否
C. QQ
D. PP
【多选题】
以下关于DASISION研究的描述,正确的是( )。
A. DASISION试验的研究终点是CCyR,而不是MMR
B. DASISION试验中,达沙替尼组与伊马替尼组获得MR4.5 的组间差异逐渐拉大
C. DASISION试验中,达沙替尼组并未显示比伊马替尼组显著降低疾病进展的风险
D. 反复发作的胸腔积液是多发的不良反应
【多选题】
IRIS研究中,伊马替尼治疗12个月内的MMR率为
A. 0.61
B. 0.39
C. 0.28
D. 0.38
【多选题】
IRIS研究随访10年, 32% 伊马替尼治疗患者由于不满意治疗反应中断治疗,>10%由于不良事件。
A. 是
B. 否
C. QQ
D. PP
【多选题】
ENRICH研究中,接受伊马替尼治疗出现低级别慢性AEs的患者换用达希纳12个月后,达到MR4.5的患者比例为
A. 0.19
B. 0.23
C. 0.42
D. 0.44
【多选题】
ENRICH研究中,接受伊马替尼治疗出现低级别慢性AEs的患者换用达希纳12个月后,达到MMR的患者比例为
A. 0.69
B. 0.78
C. 0.88
D. 0.99
【多选题】
ENESTnd研究中在伊马替尼治疗12个月内的MMR率为27%。
A. 是
B. 否
C. QQ
D. PP
【多选题】
ENESTnd 和DASISION研究中伊马替尼二线治疗患者12个月时达MMR的比例不超过
A. 0.3
B. 0.4
C. 0.5
D. 0.6
【多选题】
DASISON 研究中,达沙替尼胸腔积液的复发率是( )。
A. 0.63
B. 0.23
C. 0.91
D. 0.44
【多选题】
DASISION研究的终点是( )。
A. 6个月内,证实获得的CCyR
B. 12个月内,证实获得的CCyR
C. 6个月内,证实获得的MMR
D. 12个月内,证实获得的MMR
【多选题】
DASISION 研究4年随访中,22%的达沙替尼治疗患者中经常报告的不良事件是()。
A. 浅表水肿
B. 胸腔积液
C. 恶心
D. 疲劳
【多选题】
ENESTFreedom研究中,重启达希纳治疗后获得的治疗反应是指
A. 实现CCyR
B. 实现MMR
C. 实现CMR
D. 以上都正确
【多选题】
下列哪项是ENESTFreedom研究入组标准
A. 成人CML-CP
B. b2a2和/或b3a2转录
C. 筛查期的MMR>2年
D. ≥2年一线尼洛替尼
【多选题】
在研究2101中,换用达希纳400 mg BID后大多数获得反应的患者达到 Ph+ < 35%的时间为
A. 1个月内
B. 3个月内
C. 6个月内
D. 12个月内
【多选题】
在格列卫治疗出现的33种突变中,达希纳能够有效抑制其中种突变?
A. 15种突变
B. 20种突变
C. 32种突变
D. 33种突变
【多选题】
在服用达希纳最初的2个月,由于骨髓抑制,应每隔( )做一次全血细胞计数,之后可每( )检测一次,或者在有临床指征时进行。
A. 2周,1个月
B. 1周,2个月
C. 3周,1个月
D. 2周,2个月
【多选题】
在服药前至少4小时以及服药后至少4小时内不能进食?
A. 是
B. 否
C. QQ
D. PP