【单选题】
( ) 26. Where does the writer of "The little Prince" come from? A.England. B.France. C.America. D.China.
A. A
B. B
C. C
D. D
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答案
B
解析
B
相关试题
【单选题】
( ) 27. What does the prince do after the fox tells him a secret? A.He cares more about a flower and a sheep. B.He meets many more strange adults on other planets. C.He realizes his love for the rose and he goes back to his planet.   D.He discovers interesting things such as a snake, other roses and a fox
A. A
B. B
C. C
D. D
【单选题】
( ) 28. What does "The little Prince" mainly talk about? It' s about _________. A.the adult world B.the planet B -612 C.a rose and a fox D.the adventure of a young prince
A. A
B. B
C. C
D. D
【单选题】
( ) 29. What is the writer's main purpose(目的)in writing this passage?    A.To tell the readers his life story.    B.To tell people what kind of person his father was.    C.To tell the readers what present he got from his father.    D. To let people know how poor he was.
A. A
B. B
C. C
D. D
【单选题】
( ) 30. Why did the father not ask his son not to do this and do that?    A.Because he felt quite confident of his son.    B.Because he was born from a poor family.    C.Because he was a man of few words.    D.Because he didn't want to be much too strict with his son.
A. A
B. B
C. C
D. D
【单选题】
( ) 31. What would someone learn from this passage?    A.How to live by oneself. B.How to stand on one's own feet.    C.What a good father should do. D.What the self-important is like.
A. A
B. B
C. C
D. D
【单选题】
( ) 32. What may be the proper Chinese for the underlined part in the passage?    A.闲暇时光 B.学费 C.精神空虚 D.经济不足
A. A
B. B
C. C
D. D
【单选题】
( ) 33. Why did Natalie Smith pay for the six cars behind her? A. She had seven tickets. B. She hoped to please others. C. She knew the car drivers well. D. She wanted to show kindness.
A. A
B. B
C. C
D. D
【单选题】
( ) 34. Judy Foreman copied down the phrase because she ___ . A. thought it was beautifully written B. wanted to know what it really meant C. decided to write it on a warehouse wall D. wanted her husband to put it up in the classroom
A. A
B. B
C. C
D. D
【单选题】
( ) 35. Who came up with the phrase according to the passage? A. Judy Foreman. B. Natalie Smith. C. Anne Herbert D. Alice Johnson.
A. A
B. B
C. C
D. S
【单选题】
( ) 36. What can we infer from the last paragraph? A. People should practice random kindness to those in need. B. People who receive kindness are likely to offer it to others. C. People should practice random kindness to strangers they meet. D. People who receive kindness are likely to pay it back to the giver.
A. A
B. B
C. C
D. D
【单选题】
( ) 37.The greatest river for navigation is ___________. A. the Nile B. the Amazon C. the Mekong D. the Mississippi
A. A
B. B
C. C
D. D
【单选题】
( ) 38. From a dam, people can use the water for ___________. A. keeping the rivers clean B. only making electricity C. irrigation and making electricity D. washing clothes
A. A
B. B
C. C
D. D
【单选题】
( ) 39. The water in the river is polluted because of _____________. A. people's drinking water too much B. people's swimming in the river too much C. chemicals and other materials D. people's building a dam across a river
A. A
B. B
C. C
D. D
【单选题】
( ) 40. The best title of the passage is ___________. A. Rivers in Cities B. The importance of Rivers C. Transportation D. Natural Resources
A. A
B. B
C. C
D. D
【单选题】
) 1. Even Tony’s six-year-old son asked him ______ smoking. A. stops B. stopped C. to stop D. stopping
A. A
B. B
C. C
D. D
【单选题】
2.—What do you think of the lecture of Li Yang’s Crazy English? — I think it’s _______ , but someone thinks it’s much too ________. A. wonderful enough; bored B. enough wonderful; boring C. enough wonderful; bored D. wonderful enough; boring
A. A
B. B
C. C
D. D
【单选题】
3.—He didn’t go to the lecture this morning, did he?    — _____ .Though he was not feeling very well. A. No, he didnt B. Yes; he did C. No, he did D. Yes, he didnt
A. A
B. B
C. C
D. D
【单选题】
4. If you read a lot, your life ______ full of pleasure. A. will be B. is C. be D. was
A. A
B. B
C. C
D. D
【单选题】
5. The black bag _________ be Annas. She has a blue one. A. should B. cant C. wouldnt D. could
A. A
B. B
C. C
D. D
【单选题】
6. Susan, why are you still here? They are all ready to start. Im sorry, but I _________ when to start. A. dont tell B. wasnt told C. didnt tell D. havent told
A. A
B. B
C. C
D. D
【单选题】
7.—Why dont you choose the red tie?    —For me, it doesn’t _____ my shirt very well. A. fix B. accept C. compare D. match
A. A
B. B
C. C
D. D
【单选题】
8. — Could you tell me ______? I must find him. — Sorry.I don’t know.But he was here just now. A. where Tom was B. where Tom is C. where has Tom gone D. where can I find Tom
A. A
B. B
C. C
D. D
【单选题】
9. —What did Mr Green say to you? — What a heavy rain! How did you come here? He asked________. A. at all B. in fact C. in surprise D. as a result
A. A
B. B
C. C
D. D
【单选题】
10. I often see Tom on the playground.When I passed the playground yesterday, I saw him . A. play; playing B. to play; play C. playing; to play D. playing; play
A. A
B. B
C. C
D. D
【单选题】
11. — Mum, could I have ____________ to drink? — Oh, dear.You can only drink some water.There is _________ in the kitchen. A. anything; else something B. anything; something else C. something; else nothing D. something; nothing else
A. A
B. B
C. C
D. D
【单选题】
12. We all know that learning a foreign language _______ time and effort. A. requires B. reduces C. removes D. repeats
A. A
B. B
C. C
D. D
【单选题】
13. Her son __________ Coke, but now he __________ milk. A. is used to drinking; used to drink B. used to drink; uses to drink C. used to drink; is used to drinking D. is used to drink; is drinking
A. A
B. B
C. C
D. D
【单选题】
14. I don’t know the teacher is talking with Miss Wang. A. what B. whom C. who D. which
A. A
B. B
C. C
D. D
【单选题】
15.Millie does __________ that many people are thankful to her. A. such an important and helpful job B. so important and helpful work C. a very important and helpful job D. such an important and helpful work
A. A
B. B
C. C
D. D
【单选题】
16. I think eating more vegetables is good _______ our health. —Yes, I agree _______ you. A. at, to B. for, with C. to, to D. for, to
A. A
B. B
C. C
D. D
【单选题】
17. I often go on holiday with my parents _____ summer. A. in B. at C. on D. of
A. A
B. B
C. C
D. D
【单选题】
18. I called you at 4:00 yesterday afternoon, but nobody answered. Sorry, I ______ with my friends at that time. A. had swum B. swam C. would swim D. was swimming
A. A
B. B
C. C
D. D
【单选题】
19.––Who is on the playground? ---__________.    A. Never B. None C. No one D. A lot
A. A
B. B
C. C
D. D
【单选题】
20. The schoolboy ______ a blind man cross the street yesterday. A. helps B. helped C. will help D. has helped
A. A
B. B
C. C
D. D
【单选题】
21. —The 2010 World Expo which will last 184 days will be held in Shanghai on May 1st. —________exciting news! We shall try our best to support it. A. How B. How an C. What D. What an
A. A
B. B
C. C
D. D
【单选题】
22. They preferred ______ in bed rather than _____ horses.    A. to lie; to ride B. lying; riding C. lying; ride D. to lie; ride
A. A
B. B
C. C
D. D
【单选题】
23. —What was Jim wearing at the party? — Nothing _______. He was in his usual shirt and jeans. A. special B. simple C. important D. interesting
A. A
B. B
C. C
D. D
【单选题】
24. The 2016 Olympic Games ________ in Brazil. Would you like to go there? Maybe, if possible. A. are held B. will be held C. were held D. have been held
A. A
B. B
C. C
D. D
【单选题】
25. — David, look at the man in white over there.Can you tell me _______ ? —He is a doctor.    A. who is he B. who he is C.what does he do D. what he does
A. A
B. B
C. C
D. D
【单选题】
( ) 26.With help from a Mr. H, you can__________. A. stop wearing your watch B. get new books and objects C. finish your homework on time D. know when parents or teachers are near
A. A
B. B
C. C
D. D
推荐试题
【多选题】
CML诊断时所需检查包括( ) 。
A. 外周血涂片
B. 骨髓穿刺与骨髓活检
C. 细胞遗传学与分子学检测方法
D. 以上所有选项均错误
【多选题】
ENESTFreedom对持续深层分子学反应的定义为:最近4次PCR评估中,
A. 最近一次的评估结果不劣于MR4
B. 最近一次的评估结果不劣于MR4.5
C. MR4和MR4.5之间≤2项评估
D. MR4和MR4.5之间≤1项评估
【多选题】
ENESTFreedom研究中,无治疗生存期指进入TFR后至首次发生()的时间
A. 未实现MMR
B. 未实现MR4.5
C. 任何情况下重启尼洛替尼治疗
D. 疾病进展为加速期/白血病急变期
【多选题】
ENESTnd研究中,排除( )类型的患者。
A. 临床显著的心动过缓
B. 近期的心肌梗死
C. 充血性心脏衰竭
D. 不稳定型心绞痛
【多选题】
ENESTnd研究中的分组有( )。
A. 达希纳300mg BID
B. 达希纳400mg BID
C. 伊马替尼400mg QD
D. 伊马替尼400mg BID
【多选题】
NCCN指南推荐:伊马替尼治疗中疾病进展至AP期的患者,可采取( )治疗。
A. 临床试验
B. 达沙替尼140mg/d或尼洛替尼400mg BID
C. HSCT(如可行)
D. 停药
【多选题】
NCCN指南推荐:伊马替尼治疗中疾病进展至BC期的患者,可采取( )治疗。
A. 临床试验
B. AML或ALL诱导化疗+TKI后HSCT(如可行)
C. TKI后HSCT(如可行)
D. 以上所有选项均错误
【多选题】
Sokal评分是CML预后评估的一种方式,以下正确的包括( )
A. Sokal评分用于CML的预后评估
B. "Sokal评分<0.8
C. "Sokal评分在0.8~1.2之间
D. Sokal评分>1.2是高危患者
【多选题】
TKI治疗均的CV风险管理中,属于不可更改的因素有( )。
A. 年龄
B. 性别
C. 家族史
D. 血脂
【多选题】
TKI治疗均的CV风险管理中,属于可更改的因素有( )。
A. 高血压
B. 吸烟
C. 糖尿病
D. 饮食
【多选题】
伴有( )的患者禁用达希纳。
A. 低钾血症
B. 低镁血症
C. 长QT综合征
D. 所有选项均不正确
【多选题】
达希纳含有乳糖,所以对于( )的患者,不推荐使用。
A. 半乳糖不耐受症
B. 严重的乳糖酶缺陷
C. 葡萄糖-半乳糖吸收障碍
D. 所有选项均不正确
【多选题】
达希纳能够抑制( )激酶的自磷酸化。
A. Bcr-Abl(20-60nM)
B. PDGFR(69nM)
C. Src
D. c-Kit(210nM)
【多选题】
达希纳说明书对伊马替尼不耐受的定义是( ):
A. 尽管采用了最佳支持治疗,在任何剂量和/或治疗期间,患者仍由3或4级不良事件的持续存在而中止伊马替尼治疗。
B. 尽管采用了最佳的支持治疗,与伊马替尼治疗相关的2级不良事件仍持续时间≥1个月,或反复发生超过3次,不论是否剂量减少或中止治疗。
C. 尽管采用了最佳支持治疗,在任何剂量和/或治疗期间,患者仍由1或2级不良事件的持续存在而中止伊马替尼治疗。
D. 尽管采用了最佳的支持治疗,与伊马替尼治疗相关的2级不良事件仍持续时间≥3个月,或反复发生超过3次,不论是否剂量减少或中止治疗。
【多选题】
对伊马替尼治疗中女性CML患者计划妊娠并生产后的管理描述正确的是:( ) 。删除
A. 若处于CMR或MMR,不予治疗
B. 若丧失CMR或MMR,考虑治疗
C. 若丧失CHR,需予以治疗
D. 以上所有选项均错误
【多选题】
对伊马替尼治疗中意外妊娠的女性患者的推荐处理描述正确的是:( ) 。
A. 立即中断服用伊马替尼,以避免或减少药物潜在的致畸毒性
B. 孕3个月以上者继续服药并继续妊娠,同时严密监测胎儿发育情况,一旦发现可识别的显著异常则终止妊娠
C. 尽管已有不少发现怀孕后仍持续服用伊马替尼并产出正常婴儿的案例,但需警惕的是,母亲在妊娠的前三个月内接触伊马替尼对胎儿致畸的风险较大
D. 以上所有选项均错误
【多选题】
对于达希纳停药研究的描述,下列哪项正确
A. 丧失MMR的患者重启原剂量达希纳治疗后仍能很快重新获得分子学反应
B. 持续随访将继续评估尼达希纳长期停药后的持续缓解情况
C. 停药应在严格管理的TFR研究中进行
D. 以上均不正确
【多选题】
服用达希纳时,任何时候都应该避免进食( )。
A. 葡萄柚汁
B. 苹果汁
C. 已知的有抑制CYP3A4作用的食物
D. 香蕉汁
【多选题】
服用达希纳时,应注意的事项有( )。
A. 电解质异常
B. 肝功能异常
C. 血清脂肪酶升高
D. QT间期延长
【多选题】
符合( )其中任何一项,即可判断为CML加速期。
A. 外周血或骨髓中原始细胞占0.10-0.19
B. 外周血嗜碱粒细胞≥0.20
C. 与治疗无关的持续血小板减少或白细胞计数增高
D. 克隆演变
【多选题】
符合( )其中任何一项,即可诊断为CML急变期。
A. 外周血或骨髓中原始细胞≥0.20
B. 骨髓活检原始细胞聚集
C. 髓外原始细胞浸润
D. 所有选项均不正确
【多选题】
根据ELN指南,达到满意疗效的Bcr-Abl转录本的水平是( )。
A. TKI 治疗3个月,Bcr-Abl : ≤ 10%
B. TKI 治疗6个月,Bcr-Abl : ≤ 1%
C. TKI 治疗12个月,Bcr-Abl :≤0.1%
D. 所有选项均不正确
【多选题】
根据NCCN指南V4.2018,换用其他TKI药物治疗的指征包括
A. 随访3个月,BCR-ABLIS > 10%
B. 随访6个月,BCR-ABLIS > 10%
C. 随访12个月BCR-ABLIS 1%-10%
D. 随访>12个月BCR-ABLIS > 1%
【多选题】
根据中国CML指南2016年版,CML慢性期标准为( )。
A. 外周血或骨髓中原始细胞<0.10
B. 外周血或骨髓中原始细胞≥0.20
C. 髓外原始细胞浸润
D. 未达到诊断加速期或急变期的标准
【多选题】
关于ENESTnd和ENESTchina 研究, 以下说法正确有( )。
A. ENESTnd是3臂试验,ENESTchina是2臂试验
B. 两个试验的研究终点基本相同
C. ENESTnd中入组患者的中位年龄更大
D. ENESTnd中入组更多中高危患者
【多选题】
接受伊马替尼治疗的生产后的女性患者,( )。
A. 母乳中无伊马替尼代谢物
B. 母乳中存在伊马替尼代谢物
C. 可哺乳
D. 避免哺乳
【多选题】
目前移植存在的问题是( ) 。
A. 移植后患者生存率逐年下降
B. 复发率逐年上升
C. 死亡率逐年上升
D. 以上所有选项均错误
【多选题】
哪些属于非血液学不良反应( )。
A. 中性粒细胞减少症
B. 胃肠道异常
C. 皮疹
D. 肌痛
【多选题】
哪些属于血液学不良反应( )。
A. 血小板减少症
B. 中性粒细胞减少症
C. 腹泻
D. 贫血
【多选题】
评价二代TKI做为新诊断CML-CP患者一线治疗疗效和安全性研究的临床试验包括( )。
A. ENESTnd
B. ENESTchina
C. DASISION
D. ENESTcmr
【多选题】
如果出现血液学毒性( ),应暂停达希纳的使用。
A. 加速期:ANC<0.5×109/升或血小板<10×109/升
B. 慢性期:ANC<1.0×109/升或血小板<50×109/升)
C. 加速期:ANC<1×109/升或血小板<10×109/升
D. 慢性期:ANC<10×109/升或血小板<50×109/升
【多选题】
如果临床需要,达希纳可与造血生长因子或其他联用,例如( )。
A. EPO
B. G-CSF
C. 羟基脲
D. 阿那格雷
【多选题】
使用Sokal风险评分将Ph+ CML患者分层为高度风险,中度风险和低度风险类别,其基于具有预后意义的独立因子包括
A. 患者
B. 脾肿大程度
C. 血小板计数
D. 外周原始细胞百分比
【多选题】
属于CYP3A4诱导剂的是( )。
A. 利福平
B. 卡马西平
C. 苯巴比妥
D. 贯叶连翘
【多选题】
下列哪项是ENESTFreedom研究TFR期的PCR检测频率
A. 每4周一次
B. 每6周一次
C. 每8周一次
D. 每12周一次
【多选题】
下列哪项是ENESTFreedom研究入组标准
A. 成人CML-CP
B. b2a2和/或b3a2转录
C. 筛查期的MMR>2年
D. ≥2年一线尼洛替尼
【多选题】
下列哪项是达到MR4.5的意义
A. 无疾病进展风险
B. 远期生存延长
C. 具备TFR可能
D. 以上都不是
【多选题】
下列哪项是达希纳停药研究TFR期可能出现的不良事件
A. 骨骼肌肉痛
B. 体液潴留
C. 皮疹
D. 心血管事件
【多选题】
下列哪项是达希纳停药研究巩固期可能出现的不良事件
A. 骨骼肌肉痛
B. 胰腺炎
C. 皮疹
D. 心血管事件
【多选题】
相比格列卫,达希纳一线治疗的哪项优势与TFR相关
A. Earlier,更早的分子学反应
B. Deeper,更深的分子学反应
C. Fewer,更少的疾病进展风险
D. 以上均不正确